{"id":14805,"date":"2026-11-11T17:50:01","date_gmt":"2026-11-11T09:50:01","guid":{"rendered":"https:\/\/infernews.com\/blog\/proteus-a-mutation-resolved-world-model-for-closed-loop-protein-evolution\/"},"modified":"2026-11-11T19:03:36","modified_gmt":"2026-11-11T11:03:36","slug":"proteus-a-mutation-resolved-world-model-for-closed-loop-protein-evolution","status":"publish","type":"post","link":"https:\/\/infernews.com\/blog\/proteus-a-mutation-resolved-world-model-for-closed-loop-protein-evolution\/","title":{"rendered":"ProTEUS \u985b\u8986\u9589\u74b0\u86cb\u767d\u8cea\u7684\u300c\u7a81\u8b8a\u89e3\u6790\u4e16\u754c\u6a21\u578b\u300d"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/infernews.com\/blog\/wp-content\/uploads\/2026\/11\/ProTEUS.jpg\" alt=\"proteus logo\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u5408\u6210\u751f\u7269\u5b78\u8207\u751f\u7269\u88fd\u85e5\u9818\u57df\uff0c\u9ad8\u6d3b\u6027\u3001\u9ad8\u7a69\u5b9a\u6027\u7684\u86cb\u767d\u8cea\u9176\u4e00\u76f4\u662f\u751f\u6280\u7814\u767c\u7684\u6838\u5fc3\u8056\u676f\u3002\u7136\u800c\uff0c\u50b3\u7d71\u7684\u300c\u5b9a\u5411\u9032\u5316\uff08Directed Evolution\uff09\u300d\u8207\u7576\u524d\u4e3b\u6d41\u7684 AI \u86cb\u767d\u8cea\u8a2d\u8a08\u5de5\u5177\uff0c\u4f9d\u7136\u88ab\u56f0\u5728\u5de8\u5927\u7684\u5e8f\u5217\u7a7a\u9593\u8207\u6602\u8cb4\u7684\u6fd5\u5be6\u9a57\uff08Wet-lab\uff09\u74f6\u9838\u4e2d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6311\u9078\u86cb\u767d\u8cea\u8b8a\u7570\u6642\uff0c\u55ae\u9760\u9810\u6e2c\u672a\u5fc5\u80fd\u627e\u51fa\u771f\u6b63\u6709\u6548\u7684\u5e8f\u5217\u3002ProTEUS \u628a\u6a21\u578b\u8a2d\u8a08\u3001\u5be6\u9a57\u5ba4\u6e2c\u91cf\u548c\u4e0b\u4e00\u8f2a\u5019\u9078\u9023\u6210\u9589\u74b0\uff0c\u5354\u52a9\u7814\u7a76\u4eba\u54e1\u9010\u8f2a\u641c\u5c0b\u5177\u6709\u66f4\u9ad8\u6d3b\u6027\u7684\u8b8a\u7570\u86cb\u767d\u3002<\/p>\n\n\n<div\n    \tclass=\"align wp-block-vpb-video\"    id='vpbpVideoPlayer-1'\n    data-attributes='{&quot;source&quot;:&quot;https:\\\/\\\/yikunpku.github.io\\\/ProTEUS\\\/assets\\\/proteus-overview.mp4&quot;,&quot;repeat&quot;:true,&quot;autoplay&quot;:true,&quot;muted&quot;:true,&quot;align&quot;:&quot;&quot;,&quot;poster&quot;:&quot;&quot;,&quot;controls&quot;:{&quot;play-large&quot;:true,&quot;restart&quot;:false,&quot;rewind&quot;:true,&quot;play&quot;:true,&quot;fast-forward&quot;:true,&quot;progress&quot;:true,&quot;current-time&quot;:true,&quot;duration&quot;:false,&quot;mute&quot;:true,&quot;volume&quot;:true,&quot;pip&quot;:false,&quot;airplay&quot;:false,&quot;captions&quot;:false,&quot;settings&quot;:true,&quot;download&quot;:false,&quot;fullscreen&quot;:true},&quot;captions&quot;:[],&quot;ratio&quot;:&quot;16:9&quot;,&quot;accentColor&quot;:&quot;&quot;,&quot;lazyLoad&quot;:false,&quot;width&quot;:&quot;100%&quot;,&quot;radius&quot;:&quot;0px&quot;,&quot;resetOnEnd&quot;:false,&quot;autoHideControl&quot;:true,&quot;isSetup&quot;:false}'\n><\/div>\n\n\n<p class=\"wp-block-paragraph\">\u86cb\u767d\u8cea\u7531 20 \u7a2e\u5929\u7136\u80fa\u57fa\u9178\u6392\u5217\u7d44\u5408\u800c\u6210\uff0c\u50c5\u50c5\u4e00\u689d 300 \u500b\u80fa\u57fa\u9178\u7684\u4e2d\u578b\u86cb\u767d\u8cea\uff0c\u5176\u6f5b\u5728\u7a81\u8b8a\u7a7a\u9593\u5c31\u9ad8\u9054 $20^{300}$\uff0c\u9060\u8d85\u5b87\u5b99\u539f\u5b50\u7e3d\u6578\u3002\u9805\u76ee\u5148\u5229\u7528\u5df2\u6e2c\u91cf\u7684\u86cb\u767d\u8cea\u529f\u80fd\u8cc7\u6599\u8a13\u7df4\u6a21\u578b\uff0c\u518d\u6839\u64da\u7a81\u8b8a\u6548\u679c\u70ba\u5019\u9078\u5e8f\u5217\u6392\u5e8f\uff1b\u6bcf\u8f2a\u6e2c\u8a66 30 \u500b\u8b8a\u7570\uff0c\u53d6\u5f97\u6fd5\u5be6\u9a57\u7d50\u679c\u5f8c\uff0c\u4fbf\u7528\u7d2f\u7a4d\u6e2c\u91cf\u91cd\u65b0\u8abf\u6574\u76ee\u6a19\u9810\u6e2c\u5668\u3002\u9810\u8a13\u7df4\u8868\u793a\u5247\u4fdd\u6301\u56fa\u5b9a\uff0c\u8b93\u5f8c\u7e8c\u641c\u5c0b\u80fd\u5229\u7528\u65b0\u7d50\u679c\uff0c\u800c\u4e0d\u5fc5\u6bcf\u8f2a\u91cd\u505a\u6574\u5957\u9810\u8a13\u7df4\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ProTEUS \u5728\u5169\u7a2e\u86cb\u767d\u8cea\u4e0a\u5c55\u793a\u4e86\u9589\u74b0\u6f14\u5316\u6d41\u7a0b\u3002SacB \u7d93\u904e 3 \u8f2a\u3001\u6e2c\u8a66 90 \u500b\u8b8a\u7570\uff0c\u6700\u4f73\u7be9\u9078\u6d3b\u6027\u9054\u91ce\u751f\u578b\u7684 14.03 \u500d\uff1b\u53e6\u4e00\u689d SacB \u6f14\u5316\u8def\u7dda\u9054 12.38 \u500d\u3002ALDH \u7d93\u904e 5 \u8f2a\u3001\u6e2c\u8a66 150 \u500b\u8b8a\u7570\uff0c\u6700\u4f73\u7be9\u9078\u6d3b\u6027\u70ba\u91ce\u751f\u578b\u7684 6.85 \u500d\u3002\u9019\u4e9b\u6578\u5b57\u662f\u7be9\u9078\u6d3b\u6027\uff0c\u4e0d\u61c9\u76f4\u63a5\u89e3\u8b80\u70ba\u5df2\u8b49\u660e\u6240\u6709\u7528\u9014\u4e0b\u7684\u529f\u80fd\u63d0\u5347\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9805\u76ee\u4ea6\u4ee5 132 \u842c\u7b46\u8b8a\u7570\u6e2c\u91cf\u3001\u6db5\u84cb 161 \u7a2e\u86cb\u767d\u8cea\u80cc\u666f\u7684\u8cc7\u6599\u9032\u884c\u9810\u8a13\u7df4\u3002\u7814\u7a76\u5831\u544a\u6307\u51fa\uff0c\u628a\u529f\u80fd<mark>\u8a13\u7df4\u8cc7\u6599\u589e\u52a0 80 \u500d\u5f8c\uff0c\u6e2c\u8a66\u8aa4\u5dee\u4e0b\u964d 56.3%<\/mark>\uff1b\u5728\u9810\u8a13\u7df4\u6e2c\u5b9a\u4e2d\u7684\u7559\u51fa\u8b8a\u7570\u6e2c\u8a66\uff0cMSE \u7531 0.262 \u964d\u81f3 0.115\u3002\u9019\u4e9b\u7d50\u679c\u53cd\u6620\u7279\u5b9a\u8cc7\u6599\u8207\u8a55\u4f30\u8a2d\u5b9a\u4e0b\u7684\u8868\u73fe\uff0c\u672a\u4ee3\u8868\u6240\u6709\u86cb\u767d\u8cea\u6216\u5be6\u9a57\u689d\u4ef6\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ProTEUS \u9069\u5408\u9700\u8981\u5728\u6709\u9650\u5be6\u9a57\u6279\u6b21\u4e2d\u5b89\u6392\u86cb\u767d\u8cea\u5019\u9078\u6e2c\u8a66\u7684\u7814\u7a76\u5de5\u4f5c\u6d41\uff0c\u5c24\u5176\u662f\u80fd\u53cd\u8986\u6e2c\u91cf\u529f\u80fd\u4e26\u628a\u7d50\u679c\u7528\u65bc\u4e0b\u4e00\u8f2a\u8a2d\u8a08\u7684\u60c5\u5883\u3002\u5b83\u7684\u6210\u679c\u4ecd\u53d7\u76ee\u6a19\u86cb\u767d\u3001\u6e2c\u5b9a\u65b9\u5f0f\u548c\u5019\u9078\u7bc4\u570d\u9650\u5236\uff0c\u5be6\u9a57\u9a57\u8b49\u662f\u9589\u74b0\u4e2d\u4e0d\u53ef\u7f3a\u5c11\u7684\u4e00\u74b0\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/yikunpku.github.io\/ProTEUS\/\" rel=\"noopener\" target=\"_blank\"><strong>\u9805\u76ee\u4e3b\u9801<\/strong><\/a> \u00b7 <a href=\"https:\/\/github.com\/yikunpku\/ProTEUS\" rel=\"noopener\" target=\"_blank\"><strong>GitHub<\/strong><\/a> \u00b7 <a href=\"https:\/\/huggingface.co\/yikuuun\/proteus\" rel=\"noopener\" target=\"_blank\"><strong>\u6a21\u578b<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8a2d\u8a08\u86cb\u767d\u8cea\u8b8a\u7570\u6642\uff0c\u9810\u6e2c\u53ea\u662f\u8d77\u9ede\uff1bProTEUS \u628a\u6a21\u578b\u6392\u5e8f\u548c\u6fd5\u5be6\u9a57\u7d50\u679c\u63a5\u8d77\u4f86\uff0c\u9010\u8f2a\u6311\u9078\u66f4\u6709\u6a5f\u6703\u63d0\u5347\u529f\u80fd\u7684\u5019\u9078\u5e8f\u5217\u3002<\/p>\n","protected":false},"author":8,"featured_media":14804,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"wpai_generated_summary":"","wpai_meta_description":"","footnotes":""},"categories":[133,116,76,186,127,31,159,144,146,170],"tags":[],"class_list":["post-14805","post","type-post","status-publish","format-standard","hentry","category-133","category-agentic","category-76","category-186","category-127","category-video","category-vibe-coding","category-medical","category-146","category-170"],"_links":{"self":[{"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/posts\/14805","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/comments?post=14805"}],"version-history":[{"count":4,"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/posts\/14805\/revisions"}],"predecessor-version":[{"id":14814,"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/posts\/14805\/revisions\/14814"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/media\/14804"}],"wp:attachment":[{"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/media?parent=14805"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/categories?post=14805"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/tags?post=14805"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}