{"id":10140,"date":"2026-07-10T21:06:05","date_gmt":"2026-07-10T13:06:05","guid":{"rendered":"https:\/\/infernews.com\/blog\/druggen-2\/"},"modified":"2026-07-10T21:06:05","modified_gmt":"2026-07-10T13:06:05","slug":"druggen-2","status":"publish","type":"post","link":"https:\/\/infernews.com\/blog\/druggen-2\/","title":{"rendered":"DrugGen-2\uff1a\u628a\u75be\u75c5\u4e0a\u4e0b\u6587\u62c9\u9032\u5206\u5b50\u751f\u6210\u6d41\u7a0b"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/infernews.com\/blog\/wp-content\/uploads\/2026\/07\/pasted-c3b425a447b8.jpg\" alt=\"Logo\"><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f88\u591a\u8001\u724c\u5206\u5b50\u751f\u6210\u6a21\u578b\u53ea\u76ef\u7740\u55ae\u4e00\u86cb\u767d\u9776\u9ede\u6216\u901a\u7528\u5316\u5b78\u6027\u8cea\u505a\u689d\u4ef6\u751f\u6210\uff0c\u5f80\u5f80\u5ffd\u7565\u4e86\u540c\u4e00\u500b\u9776\u9ede\u5728\u4e0d\u540c\u75be\u75c5\u80cc\u666f\u4e0b\u884c\u70ba\u53ef\u80fd\u5b8c\u5168\u4e0d\u540c\u3002DrugGen-2 \u6b63\u662f\u91dd\u5c0d\u9019\u500b\u843d\u5dee\u800c\u4f86\uff0c\u5b83\u662f\u4e00\u500b\u7528 MeSH DAG\uff08\u75be\u75c5\u672c\u9ad4\u5c64\u7d1a\u7d50\u69cb\uff09\u52a0\u4e0a\u86cb\u767d\u5e8f\u5217\u505a\u689d\u4ef6\u8f38\u5165\u7684\u8a9e\u8a00\u6a21\u578b\uff0c\u8f38\u51fa\u7aef\u76f4\u63a5\u7d66\u51fa SMILES \u7d50\u69cb\uff0c\u65e2\u652f\u63f4 de novo \u8a2d\u8a08\uff0c\u4e5f\u80fd\u7528\u65bc\u85e5\u7269\u518d\u5229\u7528\u7be9\u9078\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9019\u500b\u9805\u76ee\u5c6c\u65bc\u958b\u6e90\u6a21\u578b\u8207\u8a13\u7df4\u6846\u67b6\u7684\u6df7\u5408\u9ad4\uff0c\u80cc\u5f8c\u4ee5 liyuesen\/druggpt \u70ba\u57fa\u5e95\uff0c\u5148\u505a Supervised Fine-Tuning\uff08SFT\uff09\uff0c\u518d\u7528 Group Relative Policy Optimization\uff08GRPO\uff09\u505a\u5f37\u5316\u5b78\u7fd2\u5fae\u8abf\uff0c\u6574\u500b\u6d41\u7a0b\u8dd1\u5728 Hugging Face transformers \u8207 TRL \u4e0a\u3002\u4f5c\u8005\u8a8d\u70ba\u820a\u505a\u6cd5\u628a\u75be\u75c5\u8207\u9776\u9ede\u5207\u5272\u770b\u5f85\uff0c\u65bc\u662f\u63d0\u51fa\u4ee5\u75be\u75c5\u70ba\u9328\u9ede\u91cd\u65b0\u7d44\u7e54\u8cc7\u6599\u7684 framing\uff0c\u9019\u4e5f\u662f\u5b83\u548c\u540c\u985e\u5de5\u5177\u6700\u5927\u7684\u5dee\u7570\u9ede\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5c0d\u505a\u8a08\u7b97\u5316\u5b78\u3001\u85e5\u7269\u7be9\u9078\u524d\u671f\u63a2\u7d22\u6216\u60f3\u5feb\u901f\u505a\u5047\u8aaa\u9a57\u8b49\u7684\u7814\u7a76\u5718\u968a\u4f86\u8aaa\uff0c\u9019\u985e\u8f38\u5165\u6bd4\u76f4\u63a5\u4e1f\u4e00\u500b\u86cb\u767d ID \u66f4\u8cbc\u8fd1\u771f\u5be6\u7528\u85e5\u60c5\u5883\u3002\u8981\u90e8\u7f72\u7684\u8a71\u53ea\u8981 clone \u5009\u5eab\u3001\u5b89\u88dd requirements\uff0c\u518d\u900f\u904e Python API \u6216 CLI \u9935\u5165\u75be\u75c5\u540d\u7a31\u3001MeSH ID \u8207 Uniprot \u5e8f\u5217\u5373\u53ef\u751f\u6210\u5019\u9078\u5206\u5b50\uff0c\u9810\u8a13\u7df4\u6b0a\u91cd\u5df2\u653e\u5728 Hugging Face \u4e0a\u65b9\u4fbf\u53d6\u7528\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0d\u904e\u8981\u7559\u610f\uff0c\u6a21\u578b\u8868\u73fe\u4ecd\u53d7\u9650\u65bc alimotahharynia\/approved_disease_target_drug \u8a13\u7df4\u96c6\u7684\u8986\u84cb\u7bc4\u570d\uff0c\u5c0d\u51b7\u9580\u75be\u75c5\u6216\u65b0\u8208\u9776\u9ede\u7684\u6cdb\u5316\u80fd\u529b\u5c1a\u672a\u6709\u516c\u958b benchmark \u76f4\u63a5\u9a57\u8b49\u3002\u5b83\u6bd4\u8f03\u9069\u5408\u4f5c\u70ba\u521d\u671f\u63a2\u7d22\u8207\u5047\u8aaa\u6392\u5e8f\u7684\u8f14\u52a9\uff0c\u800c\u975e\u53d6\u4ee3\u6fd5\u5be6\u9a57\u9a57\u8b49\u7684\u5de5\u5177\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/huggingface.co\/papers\/2607.08404\" rel=\"noopener noreferrer\" target=\"_blank\"><strong>\u9805\u76ee\u4e3b\u9801<\/strong><\/a> \u00b7 <a href=\"https:\/\/github.com\/alimotahharynia\/DrugGen-2\" rel=\"noopener noreferrer\" target=\"_blank\"><strong>GitHub<\/strong><\/a> \u00b7 <a href=\"https:\/\/arxiv.org\/pdf\/2607.08404\" rel=\"noopener noreferrer\" target=\"_blank\"><strong>Paper<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4f60\u53ef\u4ee5\u5728\u6307\u5b9a\u75be\u75c5\u8207\u86cb\u767d\u9776\u9ede\u5f8c\uff0c\u8b93\u6a21\u578b\u76f4\u63a5\u5410\u51fa\u5019\u9078\u85e5\u7269\u5206\u5b50\u3002DrugGen-2 \u88dc\u4e0a\u4e86\u4ee5\u5f80\u53ea\u91dd\u5c0d\u9776\u9ede\u6216\u901a\u7528\u6027\u8cea\u505a\u751f\u6210\u7684\u76f2\u5340\u3002<\/p>\n","protected":false},"author":8,"featured_media":10139,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ai_generated_summary":"","footnotes":""},"categories":[133,137,114,144,152,127,199],"tags":[],"class_list":["post-10140","post","type-post","status-publish","format-standard","hentry","category-133","category-api","category-clone","category-medical","category-python","category-127","category-dataset-"],"_links":{"self":[{"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/posts\/10140","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/comments?post=10140"}],"version-history":[{"count":0,"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/posts\/10140\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/media\/10139"}],"wp:attachment":[{"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/media?parent=10140"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/categories?post=10140"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/infernews.com\/blog\/wp-json\/wp\/v2\/tags?post=10140"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}